Daniel Villarreal, MD

研究抽象

In the past 20 years, our laboratory has been concerned with physiological and pathophysiological aspects of cardio-renal integration, primarily related to neurohormonal control of body fluid-volume and pressures. Current areas of research include circulatory and tissue renin-angiotensin-aldosterone axis, natriuretic peptides, 一氧化氮, 前列腺素, 最近, the newly discovered hormone leptin. This hormone is primarily synthesized and secreted by adipocytes, and one of its major well described functions is the control of appetite. 然而, in addition to its role as an "antiobesity hormone," increasing evidence suggests that leptin may have potent effects and wider actions influencing autonomic, 心血管, endocrine and renal functions. 事实上, novel observations from this and other laboratories have suggested important natriuretic and vascular actions of this peptide-hormone during pharmacological infusions. 然而, the cardio-renal role of endogenous leptin is not well characterized, either during homeostasis or in pathological conditions. Basic and clinical research from our laboratory is directed at examining mechanisms of action, hemodynamic factors and neurohormonal interactions involved in the biological expression of leptin in healthy and disease states, 比如肥胖, hypertension and heart failure.

Selected References

比利亚雷亚尔D, 大量G, 弗里曼RH. Effects of renal denervation on the sodium excretory actions of leptin in hypertensive rats. 肾脏Intl. 58:989-994, 2000.

比利亚雷亚尔D, 弗里曼R, 大量GP. Natriuretic peptides and salt sensitivity: endocrine cardio-renal integration in heart failure.  Congest 心 Fail Jan - Feb 2002;8(1):29-36.

比利亚雷亚尔D, 大量GP, Samar H, 矛R, 弗里曼RH. Effects of chronic 一氧化氮 inhibition on the renal excretory response to leptin. Obes Res June 12, 2004;(6):1006-10. 

比利亚雷亚尔D, 大量GP, 弗里曼RH, 矛R, Tchoukina I, Samar H. Leptin blockade attenuates sodium excretion in saline-loaded normotensive rats.  Mol Cell Biochem, Feb 2006;283(1-2):153-57.        

Patel SB, 大量GP, 矛RM, 弗里曼RH, 比利亚雷亚尔D. (2008) Leptin: Linking Obesity, The Metabolic Syndrome and Cardiovascular Disease.  Current 高血压 Reports 2008;10(2):131-137.  

刹帝利年代, 矛R, 比利亚雷亚尔D, 大量G, 弗里曼R, Dietz J (2009) Obesity-高血压: The Emerging Role of Leptin in Renal and Cardiovascular Dyshomeostasis. Current Opinion in Nephrology and 高血压 (in press).