姚卫东博士

教育

研究抽象

The Yao Lab studies neural mechanisms underlying reward, 影响, and prosocial 行为s in normal and disease conditions, with a focus in dopamine and the prefrontal cortex (PFC). 结合电生理学, 行为, 光遗传学, 和chemogenetics, we investigate how intrinsic and synaptic plasticity and modulation in PFC circuits are impaired in addiction, 额颞叶痴呆, 以及相关的脑部疾病. Employing molecular and cellular approaches, we also elucidate novel molecular mechanisms that regulate synapse formation, 稳定, 和修剪. We use transgenic and viral-transduced mouse models and human iPSC-derived 神经元s. 目前的项目包括:

(1) Neural circuitry and synaptic mechanisms of lost empathy in FTD.

(2) Molecular pathogenesis and synaptopathy in FTD.

(3) Prefrontal dopaminergic synaptic and circuitry mechanisms in cocaine addiction.

*招收博士后. 联系 (电子邮件保护) 应用*

选定的出版物:

菲利普斯霍奇金淋巴瘤, 戴H, Zajicek作为, Jansen-West L, Petrucelli L, 高FB, 姚WD. (2023) Dorsomedial prefrontal hypoexcitability underlies lost empathy in frontotemporal dementia. 神经元. 111(6):797-806.e6. doi: 10.1016/j.神经元.2022.12.027. Epub 2023 1月12日.

Zajicek作为, 阮H, 戴H, Skolfield MC, 菲利普斯霍奇金淋巴瘤, Burnette WJ, Javidfar B, 太阳SC, Akbarian年代, 姚WD. (2022) Cylindromatosis drives synapse pruning and weakening by promoting macroautophagy through Akt-mTOR signaling. 摩尔精神病学, 27(5):2414-2424. doi: 10.1038/s41380-022-01571-1. 2022年4月21日.

阮华，姚卫东. (2021) Loss of mGluR1-LTD following cocaine exposure accumulates Ca2+-permeable AMPA receptors and facilitates synaptic potentiation in the prefrontal cortex. J Neurogenet 35(4):358-369. doi: 10.1080/01677063.2021.1931180. 2021年6月7日.

Choi SY, Lopez-Gonzalez R, Krishnan G, 菲利普斯霍奇金淋巴瘤, Li AN, Seeley WW, 姚WD, Almeida S, 高FB. (2019) C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo. Nat >. 22(6):851-862. doi: 10.1038/s41593-019-0397-0. Epub 2019年5月13日.

Ma Q, 阮H, Peng L, Zhang M, Gack MU, 姚WD. (2017) Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, 功效, 和可塑性. 美国国家科学基金委; 114(41):E8760-E8769. doi: 10.1073 / pnas.1620153114. Epub 2017 9月25日. F1000Prime推荐. http://f1000.com/prime/731737130?bd=1

阮华，姚卫东. (2017) Cocaine promotes coincidence detection and lowers induction threshold during Hebbian associative synaptic potentiation in prefrontal cortex. J > 37(4):986-997. doi: 10.1523 / JNEUROSCI.2257-16.2016.

Hou Q, 阮H, Gilbert J, Wang G, Ma Q, 姚WD, Man HY. (2015) MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity. Nat Commun 2015年12月1日;6:100 . 45. doi: 10.1038 / ncomms10045.

吹牛的人E, 林奇K, 阮H, Verheyden J, 阳光D, 焦J, Jakovcevksi米, 攻丝机, AR, Akbarian年代, 姚WD, 高FB. (2014) Alterations in microRNA-124 and AMPA receptors contribute to social 行为al deficits in frontotemporal dementia. Nat地中海 20:1444-51.

徐天天，姚卫东. (2010) D1 and D2 dopamine receptors in separate circuits cooperate to drive associative long-term potentiation in the prefrontal cortex. 美国国家科学基金委; 107:16366-71.

Xu TX, Sotnikova TD, Liang C, Zhang J, Jung JU, Spealman RD, Gainetdinov RR, 姚WD. (2009) Hyperdopaminergic tone erodes prefrontal LTP via a D2 receptor-operated protein phosphatase gate. J > 29:14086-99.

Zhang JP, Xu TX, Hallett PJ, Watanabe M, 格兰特胡志明市, Isacson O 姚WD (2009). PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. J > 29: 2948-2960.

比尤利JM, Sotnikova T, 姚WD, Kockeritz L, Woodgett JR, Gainetdinov RR, Caron MG. (2004). An Akt/Glycogen Synthase Kinase-3 (GSK-3) signaling cascade mediates dopamine action in vivo. 美国国家科学基金委 101:5099-5104.

姚WD, Gainetdinov RR, 阿尔布克尔MI, Sotnikova TD, 比尤利JM, 希尔米, 托雷斯通用电气, 格兰特胡志明市, 卡伦·MG (2004). Identification of PSD-95 as a regulator of dopamine-mediated synaptic and 行为al plasticity. 神经元 41:625-638.

托雷斯通用电气#, 姚WD#, Mohn AR, Quan H, Caron MG (2001). Functional interaction between monoamine plasma membrane transporters and the PDZ domain-containing protein PICK1. 神经元 30: 121-134. (# Co-first作者).

姚WD, Rusch J, Poo MM, Wu CF (2000). Spontaneous acetylcholine secretion from developing growth cones of Drosophila central 神经元s in culture: effects of cAMP-pathway mutations.  J > 20: 2626-37.

链接:

推荐最近最火的赌博软件Online: Empire Innovation Scholar comes to 推荐最近最火的赌博软件, 通过哈佛, to unlock mysteries of the brain

Harvard Med School: Protein's Balancing Act May Provide Handle on Psychiatric Disease

爱荷华大学

http://www.Upstate.edu/whatsup/2018/0831-putting-heads-together-brain-researchers-collaborate-to-understand-and-battle-dementia-addiction-schizophrenia-and-more.php

http://issuu.com/Upstate/docs/magazine-magsummer18rr